Felson DT. Clinical practice. Osteoarthritis of the knee. N Engl J Med. 2006;354(8):841–8.
Google Scholar
Mundermann A, Dyrby CO, Hurwitz DE, Sharma L, Andriacchi TP. Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speed. Arthritis Rheum. 2004;50(4):1172–8.
Google Scholar
Ishijima M, Kaneko H, Hada S, Kinoshita M, Sadatsuki R, Liu L, Shimura Y, Arita H, Shiozawa J, Yusup A, et al. Osteoarthritis as a cause of locomotive syndrome: its influence on functional mobility and activities of daily living. Clin Rev Min Metab. 2016;14(2):77–104.
Google Scholar
Sadatsuki R, Ishijima M, Kaneko H, Liu L, Futami I, Hada S, Kinoshita M, Kubota M, Aoki T, Takazawa Y, et al. Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis. J Bone Min Metab. 2018;37(3):529–36.
Google Scholar
Arita H, Kaneko H, Ishibashi M, Sadatsuki R, Liu L, Hada S, Kinoshita M, Aoki T, Negishi Y, Momoeda M, et al. Medial meniscus extrusion is a determinant factor for the gait speed among MRI-detected structural alterations of knee osteoarthritis. Osteoarthr Cartil Open. 2021;3(3):100176.
Google Scholar
Hatzikotoulas K, Southam L, Stefansdottir L, Boer CG, McDonald ML, Pett JP, Park YC, Tuerlings M, Mulders R, Barysenka A, et al. Translational genomics of osteoarthritis in 1,962,069 individuals. Nature. 2025;641(8065):1217–24.
Google Scholar
Liew JW, King LK, Mahmoudian A, Wang Q, Atkinson HF, Flynn DB, Appleton CT, Englund M, Haugen IK, Lohmander LS, et al. A scoping review of how early-stage knee osteoarthritis has been defined. Osteoarthritis Cartilage. 2023;31(9):1234–41.
Google Scholar
Mahmoudian A, King LK, Liew JW, Wang Q, Appleton CT, Englund M, Haugen IK, Lohmander LS, Runhaar J, Turkiewicz A, et al. Timing is everything: towards classification criteria for early-stage symptomatic knee osteoarthritis. Osteoarthritis Cartilage. 2024;32(6):649–53.
Google Scholar
King LK, Liew JW, Mahmoudian A, Wang Q, Jansen NEJ, Stanaitis I, Hung V, Berenbaum F, Das S, Ding C, et al. Multi-centre modified Delphi exercise to identify candidate items for classifying early-stage symptomatic knee osteoarthritis. Osteoarthritis Cartilage. 2025;33(1):155–65.
Google Scholar
Guermazi A, Niu J, Hayashi D, Roemer FW, Englund M, Neogi T, Aliabadi P, McLennan CE, Felson DT. Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham osteoarthritis Study). BMJ. 2012;345:e5339.
Google Scholar
Hada S, Kaneko H, Sadatsuki R, Liu L, Futami I, Kinoshita M, Yusup A, Saita Y, Takazawa Y, Ikeda H, et al. The degeneration and destruction of femoral articular cartilage shows a greater degree of deterioration than that of the tibial and patellar articular cartilage in early stage knee osteoarthritis: a cross-sectional study. Osteoarthritis Cartilage. 2014;22(10):1583–9.
Google Scholar
Mahmoudian A, Lohmander LS, Mobasheri A, Englund M, Luyten FP. Early-stage symptomatic osteoarthritis of the knee – time for action. Nat Rev Rheumatol. 2021;17(10):621–32.
Google Scholar
Felson DT. Osteoarthritis as a disease of mechanics. Osteoarthritis Cartilage. 2013;21(1):10–5.
Google Scholar
Lo GH, McAlindon TE, Niu J, Zhang Y, Beals C, Dabrowski C, Le Graverand MP, Hunter DJ, Group OAII. Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2009;17(12):1562–9.
Google Scholar
Aso K, Shahtaheri SM, McWilliams DF, Walsh DA. Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the osteoarthritis initiative. Arthritis Res Ther. 2021;23(1):35.
Google Scholar
Shimura Y, Kurosawa H, Sugawara Y, Tsuchiya M, Sawa M, Kaneko H, Futami I, Liu L, Sadatsuki R, Hada S, et al. The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study. Osteoarthritis Cartilage. 2013;21(9):1179–84.
Google Scholar
Roemer FW, Felson DT, Wang K, Crema MD, Neogi T, Zhang Y, Nevitt MC, Marra MD, Lewis CE, Torner J, et al. Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint–the MOST study. Ann Rheum Dis. 2013;72(6):942–8.
Google Scholar
Yusuf E, Kortekaas MC, Watt I, Huizinga TW, Kloppenburg M. Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review. Ann Rheum Dis. 2011;70(1):60–7.
Google Scholar
Torres L, Dunlop DD, Peterfy C, Guermazi A, Prasad P, Hayes KW, Song J, Cahue S, Chang A, Marshall M, et al. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage. 2006;14(10):1033–40.
Google Scholar
Perry TA, Parkes MJ, Hodgson RJ, Felson DT, Arden NK, O’Neill TW. Association between bone marrow lesions & synovitis and symptoms in symptomatic knee osteoarthritis. Osteoarthritis Cartilage. 2020;28(3):316–23.
Google Scholar
Crema MD, Roemer FW, Zhu Y, Marra MD, Niu J, Zhang Y, Lynch JA, Javaid MK, Lewis CE, El-Khoury GY, et al. Subchondral cystlike lesions develop longitudinally in areas of bone marrow edema-like lesions in patients with or at risk for knee osteoarthritis: detection with MR imaging–the MOST study. Radiology. 2010;256(3):855–62.
Google Scholar
Roemer FW, Neogi T, Nevitt MC, Felson DT, Zhu Y, Zhang Y, Lynch JA, Javaid MK, Crema MD, Torner J, et al. Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study. Osteoarthritis Cartilage. 2010;18(1):47–53.
Google Scholar
Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, Kazis L, Gale DR. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med. 2001;134(7):541–9.
Google Scholar
Kubota M, Ishijima M, Kurosawa H, Liu L, Ikeda H, Osawa A, Takazawa Y, Kawasaki T, Saita Y, Kimura Y, et al. A longitudinal study of the relationship between the status of bone marrow abnormalities and progression of knee osteoarthritis. J Orthop Sci. 2010;15(5):641–6.
Google Scholar
Yusup A, Kaneko H, Liu L, Ning L, Sadatsuki R, Hada S, Kamagata K, Kinoshita M, Futami I, Shimura Y, et al. Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study. Osteoarthritis Cartilage. 2015;23(11):1858–64.
Google Scholar
Sowers MF, Hayes C, Jamadar D, Capul D, Lachance L, Jannausch M, Welch G. Magnetic resonance-detected subchondral bone marrow and cartilage defect characteristics associated with pain and X-ray-defined knee osteoarthritis. Osteoarthritis Cartilage. 2003;11(6):387–93.
Google Scholar
Moisio K, Eckstein F, Chmiel JS, Guermazi A, Prasad P, Almagor O, Song J, Dunlop D, Hudelmaier M, Kothari A, et al. Denuded subchondral bone and knee pain in persons with knee osteoarthritis. Arthritis Rheum. 2009;60(12):3703–10.
Google Scholar
Someya Y, Tamura Y, Kaga H, Nojiri S, Shimada K, Daida H, Ishijima M, Kaneko K, Aoki S, Miida T, et al. Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo health Study): a prospective cohort study. BMJ Open. 2019;9(9):e031584.
Google Scholar
Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, et al. Insulin resistance and muscle weakness are synergistic risk factors for silent lacunar infarcts: the Bunkyo health study. Sci Rep. 2021;11(1):21093.
Google Scholar
Otsuka H, Tabata H, Shi H, Kaga H, Someya Y, Abulaiti A, Naito H, Umemura F, Kakehi S, Ishijima M, et al. Associations of exercise habits in adolescence and old age with risk of osteoporosis in older adults: the Bunkyo health study. J Clin Med. 2021;10(24):5968.
Google Scholar
Adili A, Kaneko H, Aoki T, Liu L, Negishi Y, Tomura J, Wakana S, Momoeda M, Arita H, Hada S, et al. Anterior meniscus extrusion is associated with anterior tibial osteophyte width in knee osteoarthritis – The Bunkyo health study. Osteoarthr Cartil Open. 2023;5(3):100364.
Google Scholar
Negishi Y, Kaneko H, Aoki T, Liu L, Adili A, Arita H, Hada S, Momoeda M, Huang H, Tomura J, et al. Medial meniscus extrusion is invariably observed and consistent with tibial osteophyte width in elderly populations: the Bunkyo health study. Sci Rep. 2023;13(1):22805.
Google Scholar
Rosenberg TD, Paulos LE, Parker RD, Coward DB, Scott SM. The forty-five-degree posteroanterior flexion weight-bearing radiograph of the knee. J Bone Joint Surg Am. 1988;70(10):1479–83.
Google Scholar
Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494–502.
Google Scholar
Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, et al. Whole-organ magnetic resonance imaging score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage. 2004;12(3):177–90.
Google Scholar
Akai M, Doi T, Fujino K, Iwaya T, Kurosawa H, Nasu T. An outcome measure for Japanese people with knee osteoarthritis. J Rheumatol. 2005;32(8):1524–32.
Google Scholar
Guermazi A, Hayashi D, Roemer FW, Niu J, Yang M, Lynch JA, Torner JC, Lewis CE, Sack B, Felson DT, et al. Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study. Osteoarthritis Cartilage. 2010;18(11):1386–92.
Google Scholar
Hernandez-Molina G, Neogi T, Hunter DJ, Niu J, Guermazi A, Reichenbach S, Roemer FW, McLennan CE, Felson DT. The association of bone attrition with knee pain and other MRI features of osteoarthritis. Ann Rheum Dis. 2008;67(1):43–7.
Google Scholar
Davies-Tuck ML, Wluka AE, Wang Y, English DR, Giles GG, Cicuttini F. The natural history of bone marrow lesions in community-based adults with no clinical knee osteoarthritis. Ann Rheum Dis. 2009;68(6):904–8.
Google Scholar
Felson DT, Parkes MJ, Marjanovic EJ, Callaghan M, Gait A, Cootes T, Lunt M, Oldham J, Hutchinson CE. Bone marrow lesions in knee osteoarthritis change in 6–12 weeks. Osteoarthritis Cartilage. 2012;20(12):1514–8.
Google Scholar
Shibakawa A, Yudoh K, Masuko-Hongo K, Kato T, Nishioka K, Nakamura H. The role of subchondral bone resorption pits in osteoarthritis: MMP production by cells derived from bone marrow. Osteoarthritis Cartilage. 2005;13(8):679–87.
Google Scholar
Aso K, Shahtaheri SM, Hill R, Wilson D, McWilliams DF, Walsh DA. Associations of symptomatic knee osteoarthritis with histopathologic features in subchondral bone. Arthritis Rheumatol. 2019;71(6):916–24.
Google Scholar
Koushesh S, Shahtaheri SM, McWilliams DF, Walsh DA, Sheppard MN, Westaby J, Haybatollahi SM, Howe FA, Sofat N. The osteoarthritis bone score (OABS): a new histological scoring system for the characterisation of bone marrow lesions in osteoarthritis. Osteoarthritis Cartilage. 2022;30(5):746–55.
Google Scholar
Driban JB, Price L, Lo GH, Pang J, Hunter DJ, Miller E, Ward RJ, Eaton CB, Lynch JA, McAlindon TE. Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker–longitudinal relationships with pain and structural changes: data from the osteoarthritis initiative. Arthritis Res Ther. 2013;15(5):R112.
Google Scholar
Kaspiris A, Hadjimichael AC, Lianou I, Iliopoulos ID, Ntourantonis D, Melissaridou D, Savvidou OD, Papadimitriou E, Chronopoulos E. Subchondral bone cyst development in osteoarthritis: from pathophysiology to bone microarchitecture changes and clinical implementations. J Clin Med. 2023;12(3):815.
Google Scholar
Zhou F, Han X, Wang L, Zhang W, Cui J, He Z, Xie K, Jiang X, Du J, Ai S, et al. Associations of osteoclastogenesis and nerve growth in subchondral bone marrow lesions with clinical symptoms in knee osteoarthritis. J Orthop Translat. 2022;32:69–76.
Google Scholar
Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y, Zheng Q, Chen Z, Yang Y, Wan M, et al. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. J Clin Invest. 2019;129(3):1076–93.
Google Scholar
Bacon K, LaValley MP, Jafarzadeh SR, Felson D. Does cartilage loss cause pain in osteoarthritis and if so, how much? Ann Rheum Dis. 2020;79(8):1105–10.
Google Scholar
Kornaat PR, Bloem JL, Ceulemans RY, Riyazi N, Rosendaal FR, Nelissen RG, Carter WO, Le Hellio MP, Kloppenburg M. Osteoarthritis of the knee: association between clinical features and MR imaging findings. Radiology. 2006;239(3):811–7.
Google Scholar
Sowers M, Karvonen-Gutierrez CA, Jacobson JA, Jiang Y, Yosef M. Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning. J Bone Joint Surg Am. 2011;93(3):241–51.
Google Scholar
Zhu Z, Laslett LL, Jin X, Han W, Antony B, Wang X, Lu M, Cicuttini F, Jones G, Ding C. Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: a cohort study. Osteoarthritis Cartilage. 2017;25(7):1084–92.
Google Scholar
Link TM, Steinbach LS, Ghosh S, Ries M, Lu Y, Lane N, Majumdar S. Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology. 2003;226(2):373–81.
Google Scholar
Hada S, Ishijima M, Kaneko H, Kinoshita M, Liu L, Sadatsuki R, Futami I, Yusup A, Takamura T, Arita H, et al. Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis. Arthritis Res Ther. 2017;19(1):201.
Google Scholar
Hada S, Kaneko H, Liu L, Aoki T, Takamura T, Kinoshita M, Arita H, Shiozawa J, Negishi Y, Momoeda M, et al. Medial meniscus extrusion is directly correlated with medial tibial osteophyte in patients received reconstruction surgery for anterior cruciate ligament injury: A longitudinal study. Osteoarthr Cartil Open. 2022;4(4):100320.
Google Scholar
Cai G, Aitken D, Laslett LL, Pelletier JP, Martel-Pelletier J, Hill C, March L, Wluka AE, Wang Y, Antony B, et al. Effect of intravenous Zoledronic acid on tibiofemoral cartilage volume among patients with knee osteoarthritis with bone marrow lesions: A randomized clinical trial. JAMA. 2020;323(15):1456–66.
Google Scholar
Neogi T, Nevitt M, Niu J, Sharma L, Roemer F, Guermazi A, Lewis CE, Torner J, Javaid K, Felson D. Subchondral bone attrition May be a reflection of compartment-specific mechanical load: the MOST study. Ann Rheum Dis. 2010;69(5):841–4.
Google Scholar
Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, et al. Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Min Metab. 2009;27(5):620–8.
Google Scholar
Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The Framingham osteoarthritis study. Arthritis Rheum. 1987;30(8):914–8.
Google Scholar
Duncan ST, Khazzam MS, Burnham JM, Spindler KP, Dunn WR, Wright RW. Sensitivity of standing radiographs to detect knee arthritis: a systematic review of level I studies. Arthroscopy. 2015;31(2):321–8.
Google Scholar
Eckersley T, Faulkner J, Al-Dadah O. Inter- and intra-observer reliability of radiological grading systems for knee osteoarthritis. Skeletal Radiol. 2021;50(10):2069–78.
Google Scholar
Miura Y, Ozeki N, Katano H, Aoki H, Okanouchi N, Tomita M, Masumoto J, Koga H, Sekiya I. Difference in the joint space of the medial knee compartment between full extension and Rosenberg weight-bearing radiographs. Eur Radiol. 2022;32(3):1429–37.
Google Scholar
Hunter DJ, Guermazi A, Roemer F, Zhang Y, Neogi T. Structural correlates of pain in joints with osteoarthritis. Osteoarthritis Cartilage. 2013;21(9):1170–8.
Google Scholar
Neogi T, Guermazi A, Roemer F, Nevitt MC, Scholz J, Arendt-Nielsen L, Woolf C, Niu J, Bradley LA, Quinn E, et al. Association of joint inflammation with pain sensitization in knee osteoarthritis: the multicenter osteoarthritis study. Arthritis Rheumatol. 2016;68(3):654–61.
Google Scholar
Stefanik JJ, Frey-Law L, Segal NA, Niu J, Lewis CE, Nevitt MC, Neogi T. The relation of peripheral and central sensitization to muscle co-contraction: the MOST study. Osteoarthritis Cartilage. 2020;28(9):1214–9.
Google Scholar
Allado E, Wittoek R, Ferrero S, Albuisson E, Chary-Valckenaere I, Roux C, Loeuille D. Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score. PLoS ONE. 2020;15(6):e0234972.
Google Scholar
Leigheb M, Guzzardi G, Barini M, Abruzzese M, Riva S, Pasche A, Pogliacomi F, Rimondini L, Stecco A, Grassi FA, et al. Role of low field MRI in detecting knee lesions. Acta Biomed. 2018;90(1–S):116–22.
Google Scholar
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